HELPING THE OTHERS REALIZE THE ADVANTAGES OF PKRRATING

The interfacial residues are highly conserved amongst eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements reveal the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations assistance a design the place activating RNA serves like a scaffold to bind multiple PKR monomers, increasing

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